Author

P. C. Stirling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L.-A. Fournier· 3 shared A. Kumar· 2 shared A. Shanks· 2 shared E. Su· 2 shared E. Y.-C. Chang· 2 shared J. P. Wells· 2 shared M. Hirst· 2 shared T. Smith· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

L.-A. Fournier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPR screen identifies KEAP1 perturbation as a vulnerability of ARID1A-deficient cells

L.-A. Fournier, F. Kalantari, J. P. Wells, J. S. Lee, G. Trigo-Gonzalez, M. M. Moksa, T. Smith, J. White, A. Shanks, L. Wang, E. Su, Y. Wang, D. G. Huntsman, M. Hirst, P. C. Stirling

The paper identifies KEAP1 as a genetic dependency in ARID1A-deficient clear cell ovarian carcinoma cells through a genome-wide CRISPR screen, showing KEAP1 perturbation leads to growth inhibition.

bioRxiv · Nov 14, 2023Cancer Biology

Global prediction of candidate R-loop binding and R-loop regulatory proteins

L.-A. Fournier, A. Kumar, T. Smith, E. Su, M. Moksa, M. Hirst, P. C. Stirling

The paper develops a random forest classifier to predict R-loop binding proteins using proteomic features and amino acid composition, and validates new R-loop modulating proteins through CRISPR screening.

bioRxiv · Aug 9, 2021 · PreprintCell Biology

DYNLL1 mis-splicing is associated with replicative genome instability in SF3B1 mutant cells

A. S. Tam, S. Tsai, E. Y.-C. Chang, V. Mathew, A. Shanks, T. R. Docking, A. Kumar, D. G. Bernard, A. Karsan, P. C. Stirling

This study shows SF3B1 mutations cause DYNLL1 mis-splicing, leading to genome instability through altered DNA repair and PARP inhibitor sensitivity.

bioRxiv · May 26, 2021 · PreprintCell Biology

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

E. Y.-C. Chang, J. P. Wells, S.-H. Tsai, Y. Coulombe, Y. A. Chan, Y. D. Zhu, L.-A. Fournier, P. Hieter, J.-Y. Masson, P. C. Stirling

The paper identifies MRE11-RAD50-NBS1's role in suppressing R-loops at transcription-replication conflicts through non-nucleolytic functions and Fanconi Anemia pathway interactions.

bioRxiv · Nov 17, 2018Cell Biology