PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response
J. Li, M. M. Kaneda, J. Ma, M. Li, K. Patel, T. Koga, A. L. Sarver, F. Furnari, B. Xu, S. Dhawan, J. Ning, H. Zhu, A. Wu, G. You, T. Jiang, , C. C. Chen
The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.
Proceedings of the National Academy of Sciences · Apr 12, 2021Peer-reviewedCancer Biology