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Primary ORCID profile (0000-0001-5733-4261 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
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5 papers
Recent·Most cited
J. J. Hou, M. McMahon, J. N. Sarkaria, C. C. Chen, D. J. Odde
This paper develops a physics-based cell migration simulator to identify physical biomarkers for glioblastoma, linking mechanical parameters to transcriptomic data and drug response.
Neuro-Oncology Advances · Nov 2, 2024Peer-reviewedBioengineering
J. Ning, N. Gavil, S. Wu, S. Wijeyesinghe, E. Weyu, J. Ma, M. Li, F.-N. Grigore, S. Dhawan, A. G. J. Skorput, S. C. Musial, C. C. Chen, D. Masopust, P. C. Rosato
This study shows that virus-specific memory T cells reside in glioblastoma and can be reactivated to improve survival in a mouse model.
bioRxiv · Sep 6, 2021 · PreprintImmunology
J. Li, M. M. Kaneda, J. Ma, M. Li, K. Patel, T. Koga, A. L. Sarver, F. Furnari, B. Xu, S. Dhawan, J. Ning, H. Zhu, A. Wu, G. You, T. Jiang, , C. C. Chen
The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.
Proceedings of the National Academy of Sciences · Apr 12, 2021Peer-reviewedCancer Biology
T. Koga, J. A. Benitez, I. A. Chaim, S. Markmiller, A. D. Parisian, R. F. Hevner, K. M. Turner, F. M. Hessenauer, M. D'Antonio, N.-p. D. Nguyen, S. Saberi, J. Ma, S. Miki, A. D. Boyer, J. Ravits, , F. B. Furnari
This paper introduces cancer avatar models using genetically engineered hiPSCs to study tumor development and heterogeneity in glioblastoma.
bioRxiv · Oct 25, 2019Cancer Biology
K. K. Chahal, J. Li, I. Kufareva, M. Parle, D. D. Durden, R. Wechsler-Reya, C. C. Chen, R. Abagyan
The paper shows Nilotinib inhibits Hedgehog signaling in medulloblastoma by directly targeting Smoothened, outperforming Vismodegib in cell lines and xenograft models.
bioRxiv · Mar 25, 2019Cancer Biology