T. Koga

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

This study identifies ULK1 as the kinase responsible for phosphorylating p62, which activates NRF2 in a redox-independent manner through retention of KEAP1 in p62 bodies.

Structural insights into AT-rich DNA recognition by SALL family proteins

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

Targeting Glioblastoma Signaling and Metabolism with A Re-Purposed Brain-Penetrant Drug

This study identifies fluoxetine as a potential therapy for glioblastoma by inhibiting SMPD1 and enhancing temozolomide efficacy, with real-world evidence suggesting improved survival.

SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability

This study shows SMARCB1 loss affects neuronal differentiation and cell stability differently based on the differentiation state, contributing to ATRT tumorigenesis.

Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development

This paper introduces cancer avatar models using genetically engineered hiPSCs to study tumor development and heterogeneity in glioblastoma.