S. Dhawan

LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK

This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.

The clock-modulatory activity of Nobiletin suppresses adipogenesis via Wnt signaling

This study shows Nobiletin suppresses adipogenesis by enhancing the circadian clock and activating Wnt signaling, leading to reduced fat mass and body weight in mice.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

Therapeutic activation of virus-specific resident memory T cells within the glioblastoma microenvironment

This study shows that virus-specific memory T cells reside in glioblastoma and can be reactivated to improve survival in a mouse model.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

Modular, part-based control of gene expression response time using protein degradation tags

The paper introduces a modular genetic system that controls gene expression response time by adjusting protein degradation rates using tags with varying protease affinities.