A. Salas

Mitochondrial dysfunction: unraveling the elusive biology behind anti-TNF response during ulcerative colitis

The paper investigates the relationship between mitochondrial dysfunction and anti-TNF treatment response in ulcerative colitis using both murine and human samples, finding metabolic pathways and mitochondrial homeostasis are involved.

Interpretable Inflammation Landscape of Circulating Immune cells

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease

The paper identifies macrophage and neutrophil heterogeneity in inflammatory bowel disease using single-cell and spatial transcriptomics, revealing distinct subtypes and their potential roles in disease.

Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease

This study shows that diet can prevent ileo-colonic inflammation in a Crohn's disease model by reducing segmented filamentous bacteria (SFB) abundance.

Intranasal inoculation of Cryptococcus neoformans in mice produces nasal infection with rapid brain dissemination

This study shows that intranasal infection with Cryptococcus neoformans in mice leads to rapid brain dissemination and nasal colonization within hours.

Shallow metagenomics with Nanopore sequencing in canine fecal microbiota improved bacterial taxonomy and identified an uncultured CrAssphage

The paper uses shallow long-read metagenomics with Nanopore sequencing on pooled canine fecal samples to improve taxonomic resolution and identify an uncultured CrAssphage.