Author

C. Coelho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:mouse· 6 Assay:proteomics· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:cell-cell communication· 2 Organism:fungi (other)· 2

Frequent Co-Authors

A. Casadevall· 9 shared A. Alanio· 3 shared E. Camacho· 3 shared M. Maryam· 2 shared R. J. B. Cordero· 2 shared A. Berhe· 1 shared A. Bocca· 1 shared A. Dziedzic· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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9 shared papersMicrobiology

A. Casadevall

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Author profile →

10 papers

Recent·Most cited

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

C. J. Crawford, L. Liporagi-Lopes, C. Coelho, S. R. Santos Junior, A. M. Nicola, M. P. Wear, S. Oscarson, A. Casadevall

This paper presents two semi-synthetic glycoconjugate vaccines targeting Cryptococcus neoformans GXM, showing immunogenicity and cross-reactivity in mice.

bioRxiv · Feb 2, 2024 · PreprintImmunology

Cryptococcus neoformans rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia

V. Francis, C. Liddle, E. Camacho, M. Kulkarni, S. R. Junior, J. A. Harvey, E. R. Ballou, D. D. Thomson, J. M. Hardwick, A. Casadevall, J. Witton, C. Coelho

bioRxiv · Nov 13, 2023Microbiology

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites

C. Coelho, S. Marquez, B. T. Tentokam, A. Berhe, k. Miura, C. Long, S. Healy, I. Sagara, S. Kleinstein, P. Duffy

This study identifies antibody gene features linked to binding and functional activity in vaccine-derived human mAbs against malaria parasites, showing adjuvant effects on clonotype diversity.

bioRxiv · Aug 1, 2023 · PreprintImmunology

Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal-macrophage interaction

E. H. Jung, Y.-D. Park, Q. Dragotakes, L. S. Ramirez, D. F. Smith, A. Dziedzic, P. R. Williamson, A. Jedlicka, A. Casadevall, C. Coelho

This study identifies fungal proteins released by Cryptococcus neoformans during macrophage infection, revealing their potential role in modulating virulence and host-pathogen interactions.

bioRxiv · Sep 21, 2021Microbiology

Intranasal inoculation of Cryptococcus neoformans in mice produces nasal infection with rapid brain dissemination

C. Coelho, E. Camacho, A. Salas, A. Alanio, A. Casadevall

This study shows that intranasal infection with Cryptococcus neoformans in mice leads to rapid brain dissemination and nasal colonization within hours.

bioRxiv · Jul 20, 2019Immunology

Galectin-3 inhibits Paracoccidioides brasiliensis growth and impacts paracoccidioidomycosis through multiple mechanisms

O. Hatanaka, C. P. Rezende, P. Moreno, F. F. Fernandes, P. K. M. Oliveira-Brito, R. Martinez, C. Coelho, M. C. Roque-Barreira, A. Casadevall, F. Almeida

This study shows Galectin-3 inhibits Paracoccidioides brasiliensis growth and affects extracellular vesicle stability, suggesting a direct antimicrobial role in paracoccidioidomycosis.

bioRxiv · Feb 23, 2019Microbiology

Cryptococcus neoformans secretes small molecules that inhibit IL-1β inflammasome-dependent secretion

P. H. Bürgel, C. L. Marina, P. H. V. Saavedra, P. Albuquerque, P. H. Holanda, R. d. A. Castro, H. Heyman, C. Coelho, R. J. B. Cordero, A. Casadevall, J. Nosanchuk, E. Nakayasu, R. C. May, A. H. Tavares, A. Bocca

This study shows that secreted molecules from Cryptococcus neoformans inhibit inflammasome-dependent macrophage responses, reducing antifungal activity and enhancing fungal survival.

bioRxiv · Feb 19, 2019Immunology

The enigmatic role of fungal annexins: the case of Cryptococcus neoformans

M. Maryam, M. S. Fu, A. Alanio, E. Camacho, G. Diego, E. E. Faneuff, N. T. Grossman, A. Casadevall, C. Coelho

This study investigates the role of annexins in Cryptococcus neoformans, finding that the annexin gene is not essential for virulence or mating but affects titan cell formation.

bioRxiv · Jan 31, 2019Microbiology

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

B. Hommel, L. Mukaremera, R. J. B. Cordero, C. coelho, C. A. Desjardins, A. Sturny-Leclere, G. Janbon, J. Perfect, J. A. Fraser, A. Casadevall, C. A. Cuomo, F. Dromer, K. Nielsen, A. Alanio

This study identifies environmental and genetic factors that regulate titan cell formation in Cryptococcus neoformans using an optimized in vitro assay.

bioRxiv · Mar 22, 2018Microbiology

Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles

C. Coelho, L. Brown, M. Maryam, M. C. Burnet, J. E. Kyle, H. M. Heyman, R. Vij, J. Ramirez, R. Prados-Rosales, G. Lauvau, E. S. Nakayasu, N. R. Brady, A. Hamacher-Brady, I. Coppens, A. Casadevall

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.

bioRxiv · Jan 20, 2018Microbiology