M. Ruiz

A Hollow TFG Condensate Spatially Compartmentalizes the Early Secretory Pathway

The paper shows that TFG forms a hollow condensate at the ER-Golgi interface, acting as a molecular sieve that separates anterograde and retrograde carriers.

Interpretable Inflammation Landscape of Circulating Immune cells

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

Fast and efficient root phenotyping via pose estimation

This paper introduces a segmentation-free root phenotyping method using pose estimation, showing high accuracy and efficiency compared to segmentation-based approaches.

A NRF2/beta3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stress

This study identifies a NRF2/beta3-adrenoreceptor axis that enhances antioxidant defenses and metabolic rewiring via the pentose-phosphate pathway, protecting cardiac function under stress.

Origin of biogeographically distinct ecotypes during laboratory evolution

This study shows how mutations in microbial species lead to resource partitioning and improved community productivity in a simulated subsurface environment.

Cryo-EM structure of the Agrobacterium tumefaciens T-pilus reveals the importance of positive charges in the lumen

The paper reports cryo-EM structures of Agrobacterium tumefaciens T-pilus and related N-pilus, showing positive charges in the lumen are functionally important.

Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis And Embryogenesis

The paper identifies a conserved pathway involving AdipoR1/2-derived S1P that maintains membrane homeostasis by regulating fatty acid desaturase expression in mice, human cells, and C. elegans.

Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation

This study shows that oleate induces β-cell proliferation in rats via unsaturated very long-chain sphingolipids, mediated by ACBP and ELOVL1.

AdipoR2 is Essential for Membrane Lipid Homeostasis in Response to Dietary Saturated Fats

The paper identifies AdipoR2 as essential for maintaining membrane lipid homeostasis by counteracting saturated fat-induced membrane rigidification across species.

Bent DNA bows as amplifiers and biosensors for detecting DNA-interacting salts and molecules

This study develops bent DNA bows to amplify and detect DNA interactions with salts and molecules, enabling sensitive and cost-effective analysis using gel electrophoresis and the modified Hill equation.

MK2-deficient mice are bradycardic and display delayed hypertrophic remodelling in response to a chronic increase in afterload

This study examines the cardiac phenotype of MK2-deficient mice, finding altered autonomic regulation, increased metabolic gene expression, reduced mitochondrial Ca2+-sensitivity, and delayed hypertrophic remodeling in response to pressure overload.

Faster diffusive dynamics of histone-like nucleoid structuring proteins in live bacteria caused by silver ions

This study shows that silver ions increase the diffusive motion of H-NS proteins in live bacteria by weakening their DNA binding through DNA dehybridization.

Evolutionary forces affecting synonymous variations in plant genomes

The paper investigates the evolutionary forces shaping synonymous variations in plant genomes, finding that GC-biased gene conversion is more prevalent and stronger than selection in most species.