E. Lorenzen

Unpacking Unstructured Data: A Pilot Study on Extracting Insights from Neuropathological Reports of Parkinson's Disease Patients using Large Language Models

This study uses large language models to structure unstructured neuropathological reports from Parkinson's disease patients, improving data consistency and enabling integration with clinical and genetic data.

Four centuries of commercial whaling eroded 11,000 years of population stability in bowhead whales

This study uses fossil data and modeling to show that commercial whaling caused genetic diversity loss in bowhead whales, threatening their resilience to future climate change.

Late Pleistocene polar bear genomes reveal the timing of allele fixation in key genes associated with Arctic adaptation

This study uses Late Pleistocene polar bear genomes to assess the timing of allele fixation in key Arctic adaptation genes, finding most alleles were fixed before 70,000 years ago, with some recent fixes in APOB, LYST, and TTN.

The origins and diversification of Holarctic brown bear populations inferred from genomes of past and present populations

This study uses ancient and modern genomes to trace the evolutionary history and population dynamics of brown bears across the Holarctic region.

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

This study identifies that MRGPRX4 interacts with RAMP2, reducing its signaling and surface expression, and predicts the structure of the MRGPRX4-RAMP2 complex.

Ancient dolphin genomes reveal rapid repeated adaptation to coastal waters

This study uses ancient dolphin genomes to show rapid adaptation to coastal habitats through standing genetic variation and gene flow from coastal to pelagic populations.

Impact of Holocene environmental change on the evolutionary ecology of an Arctic top predator

This study examines how Holocene environmental changes impacted the evolutionary ecology of Greenlandic polar bears using genomics, isotopic analysis, morphometrics, and ecological modeling.

Genomic insights into the evolutionary relationships and demographic history of kiwi

This study uses genomic data to analyze the evolutionary relationships and demographic history of kiwi species, revealing low gene-tree discordance and signs of post-divergence gene flow.

Sex and size matter: foraging ecology of offshore harbour porpoises in waters around Greenland

The paper examines sex and size differences in the foraging ecology of harbour porpoises using stable isotope analysis, finding females have higher trophic levels and larger ecological niches.

Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome

This study identifies GPCR-RAMP interactions using a suspension bead array assay, revealing widespread interactions among secretin-like GPCRs and RAMPs.

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Co-receptor CCR5

The paper develops a fluorescence assay to study high-affinity chemokine analogs that show ligand bias at CCR5, finding they bind with subnanomolar affinities and occupy a site not accessible to native chemokines.