S. Lei

A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism

This study shows that a ketogenic diet enhances the effectiveness of glutamine metabolism inhibitors in pancreatic cancer by increasing tumor reliance on glutamine for energy.

The Effects of Functional Training on Muscle Strength in Athletes: A Meta-Analysis

This study evaluates functional training's impact on athlete muscle strength compared to traditional resistance training, finding moderate to large effects on maximum strength, power, and muscle endurance.

Characterization of sediment and granite hosted deep underground research laboratories reveals diverse microbiome functions, limited temporal variation and substantial genomic conservation

The paper characterizes microbiomes in underground research labs, finding genomic conservation and similar functional profiles despite environmental differences.

Methanotrophic Methanoperedens archaea host diverse and interacting extrachromosomal elements

The paper identifies and characterizes diverse extrachromosomal elements in Methanoperedens archaea, including mini-Borgs and viruses, and shows their genetic exchange and potential impact on archaeal activity.

Virus-derived circular RNAs populate hepatitis C virus-infected cells

The paper identifies virus-derived circular RNAs (vcircRNAs) in hepatitis C virus-infected cells, showing they enhance viral RNA abundance and promote translation of novel viral proteins.

Long-B prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

Vitamin interdependencies predicted by metagenomics-informed network analyses validated in microbial community microcosms

The paper predicts vitamin interdependencies in microbial communities using metagenomics-informed network analysis and validates these predictions in microcosms.

PvC3H29 interacts with and inhibits DNA binding of PvNAPs to finetune leaf senescence in switchgrass (Panicum virgatum)

PvC3H29 interacts with PvNAP1&2 to inhibit their transactivation on chlorophyll catabolism and leaf senescence in switchgrass.

Mechanism of innate immune reprogramming by a fungal meningitis pathogen

The paper identifies a secreted fungal effector, Cpl1, that promotes virulence by enhancing type 2 inflammation through reprogramming innate immunity.

Stop codon recoding is widespread in diverse phage lineages and has the potential to regulate translation of late stage and lytic genes

The paper surveys stop codon recoding in bacteriophages, finding it widespread and suggesting it regulates gene expression and lysis timing.

Meanders as a scaling motif for understanding of floodplain soil microbiome and biogeochemical potential at the watershed scale

The paper investigates microbial metabolic potential in floodplain soils along a river corridor, finding that meander-bound regions predict biogeochemical capacities at the watershed scale.

Diverse ATPase proteins in mobilomes constitute a large potential sink for prokaryotic host ATP

The paper identifies ATPase proteins in mobilome genomes as potential energy sinks that may suppress host energy consumption during replication.

Wide distribution of alternatively coded Lak megaphages in animal microbiomes

The paper identifies a wide distribution of alternatively coded Lak phages in animal microbiomes, including new genomes and associations with specific animal types.

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

Controlled-release urea combined with potassium chloride improved the soil fertility and growth of Italian ryegrass

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

Clades of huge phage from across Earth’s ecosystems

The paper identifies major clades of large phage genomes across diverse ecosystems and highlights their expanded genetic repertoires and potential functional roles.