A. Sugihara

Optineurin provides a mitophagy contact site for TBK1 activation

This study identifies OPTN as a platform for TBK1 activation during mitophagy, showing OPTN facilitates TBK1 assembly at mitochondrial-autophagosome contact sites and enhances its activation through hetero-autophosphorylation.

CUB domain-containing protein 1 controls HGF responses by integrating Src and Met-STAT3 signaling

This study identifies CDCP1 as a key regulator of HGF signaling by integrating Src and Met-STAT3 pathways, showing its role in cell invasion and renal growth.