T. Fujino

Optineurin provides a mitophagy contact site for TBK1 activation

This study identifies OPTN as a platform for TBK1 activation during mitophagy, showing OPTN facilitates TBK1 assembly at mitochondrial-autophagosome contact sites and enhances its activation through hetero-autophosphorylation.

Somatic mutation rates scale with time not growth rate in long-lived tropical trees

This study finds that somatic mutation rates in tropical trees scale with time, not growth rate, showing a constant mutation rate per year across species with different growth rates.

PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer

The paper identifies two single-nucleotide variants in the PTEN-induced kinase 1 gene associated with lower recurrence rates in colorectal cancer patients undergoing adjuvant chemotherapy.

Comprehensive analysis of the effect of mRNA sequences on translation efficiency and accuracy

The paper analyzes how mRNA sequences affect translation efficiency and accuracy, identifying key codons and bases that influence ribosome behavior and misreading rates.

Single-nucleotide substitution determines pollen production in Japanese cedar

This study identifies a single-nucleotide substitution in the TKPR1 gene that determines pollen production in Japanese cedar and suggests its potential application in creating pollen-free plants.