Optineurin provides a mitophagy contact site for TBK1 activation
K. Yamano, M. Sawada, R. Kikuchi, K. Nagataki, W. Kojima, A. Sugihara, T. Fujino, K. Tanaka, G. Hayashi, H. Murakami, N. Matsuda
This study identifies OPTN as a platform for TBK1 activation during mitophagy, showing OPTN facilitates TBK1 assembly at mitochondrial-autophagosome contact sites and enhances its activation through hetero-autophosphorylation.
bioRxiv · Feb 24, 2023Cell Biology