Author

R. A. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. J. Abraham· 3 shared M. Geyer· 2 shared S. Dust· 2 shared A. Berezovskaya· 1 shared A. D. Durbin· 1 shared A. Font-Tello· 1 shared A. Gusev· 1 shared A. L. Greenleaf· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

B. J. Abraham

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

N. Prutsch, S. He, A. Berezovskaya, A. D. Durbin, N. V. Dharia, K. Stegmaier, J. D. Matthews, L. Hare, S. D. Turner, L. Kenner, O. Merkel, R. A. Young, B. J. Abraham, A. T. Look, M. W. Zimmerman

This study identifies STAT3's role in driving MYC expression and oncogenesis in ALCL by cooperating with a core transcriptional regulatory circuit.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

Predicting master transcription factors from pan-cancer expression data

J. Reddy, M. A. S. Fonseca, R. I. Corona, R. Nameki, F. Segato Dezem, I. A. Klein, H. Chang, D. Chaves-Moreira, L. Afeyan, T. M. Malta, X. Lin, F. Abbasi, A. Font-Tello, T. Sabedot, P. Cejas, , K. Lawrenson

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

bioRxiv · Nov 12, 2019Cancer Biology

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

M. Krajewska, R. Dries, A. V. Grassetti, S. Dust, Y. Gao, H. Huang, B. Sharma, D. S. Day, N. Kwiatkowski, M. Pomaville, O. Dodd, E. Chipumuro, T. Zhang, A. L. Greenleaf, G.-C. Yuan, , R. E. George

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.

bioRxiv · Nov 30, 2018Cancer Biology