B. J. Abraham

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Specific oncogene activation of the cell of origin in mucosal melanoma

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

This study identifies STAT3's role in driving MYC expression and oncogenesis in ALCL by cooperating with a core transcriptional regulatory circuit.

Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma

This study shows retinoic acid reprograms enhancer landscapes in MYCN-amplified neuroblastoma cells, downregulating MYCN and inducing sympathetic differentiation.

Predicting master transcription factors from pan-cancer expression data

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.