S. J. Diskin

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

Advancing childhood cancer research through young investigator and advocate collaboration

This paper describes a collaborative model between young investigators and cancer advocates to enhance pediatric cancer research through improved communication and team science.

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

The paper identifies a regulatory polymorphism in LMO1 that reduces neuroblastoma risk by preventing the adrenergic cell state in zebrafish and humans.

ALT in Pediatric High-Grade Gliomas Can Occur without ATRX Mutation and is Enriched in Patients with Pathogenic Germline MMR Variants

This paper identifies ALT in pediatric high-grade gliomas without ATRX mutations and links it to germline MMR variants.

Integrative genomics identifies lncRNA regulatory networks across 1,044 pediatric leukemias and extra-cranial solid tumors

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation

This study identifies lineage-specific transcription factors and super-enhancers driving neuroblastoma self-renewal and differentiation using ATRA treatment and CRISPR screening.

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.