ImmunologybioRxiv
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Z. A. Bittner, X. Liu, S. Shankar…·A. N. Weber
The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.
DOI 10.1084/jem.20201656