A. N. Weber

BTK and MMP9 regulate NLRP3 inflammasome-dependent cytokine and NET responses in primary neutrophils.

This paper shows that BTK and MMP-9 negatively regulate NLRP3 inflammasome activity in neutrophils, affecting cytokine and NET release.

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

This study identifies naRNA as a pre-assembled composite DAMP in neutrophils that drives NET formation and inflammation via TLR8/TLR13, redefining NETs as intentional inflammatory agents.

Chitin oligomers directly promote lymphoid innate and adaptive immune cell activation

This study shows chitin oligomers activate lymphoid innate and adaptive immune cells, including NK cells, B cells, and dendritic cells, through TLR2, expanding their role beyond myeloid cells.

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

The failure of B cells to induce non-canonical MYD88 splice variants correlates with lymphomagenesis via sustained NF-κB signaling

The paper shows that B cells lack a negative feedback loop that normally limits TLR signaling through MYD88 splice variants, leading to sustained NF-κB activation and lymphomagenesis.