Author

S. Shankar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1 Biophysics· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Coscia· 1 shared A. de Carvalho· 1 shared A. De Chellis· 1 shared A. Delor· 1 shared A. Geary-Teeter· 1 shared A. Goodrum· 1 shared A. Griffiths· 1 shared A. M. Chinnaiyan· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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1 shared paperMicrobiology

A. Coscia

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

V. Shankar, J. Wilhelmy, B. Michael, L. Cervantes, V. Mallajosyula, R. Davis, M. Snyder, S. Younis, W. H. Robinson, S. Shankar, P. Mischel, H. Bonilla, M. Davis

This study identifies elevated oxidative stress in both ME/CFS and Long COVID patients through blood cell analysis, suggesting shared molecular mechanisms and potential therapeutic targets.

bioRxiv · May 4, 2024 · PreprintImmunology

Active hydraulics and odd elasticity of muscle fibers

S. Shankar, L. Mahadevan

This study develops a multiscale model of muscle as an active sponge to explain contraction dynamics, highlighting hydraulic oscillations and nonreciprocal viscoelasticity.

bioRxiv · Feb 20, 2022 · PreprintBiophysics

Supercharged Cellulases Show Reduced Non-Productive Binding, But Enhanced Activity, on Pretreated Lignocellulosic Biomass

B. Nemmaru, J. Douglass, J. M. Yarbrough, A. De Chellis, S. Shankar, A. Thokkadam, A. Wang, S. P. S. Chundawat

This study shows that supercharging cellulase surface charge improves hydrolytic activity on pretreated biomass by reducing non-productive binding.

bioRxiv · Oct 17, 2021 · PreprintBioengineering

Subclonal evolution and expansion of THY1-positive cells is associated with recurrence in glioblastoma

W. N. Al-Holou, H. Wang, V. Ravikumar, M. Oneka, R. Verhaak, H. Kim, D. Pratt, S. Camelo-Piragua, C. Speers, D. Wahl, S. Shankar, T. Hollon, O. Sagher, J. Heth, K. Muraszko, , A. Rehemtulla

This paper identifies THY1-positive, mesenchymal/stem-like cells as drivers of glioblastoma recurrence and shows that targeting TGFβ signaling can restore sensitivity to therapy.

bioRxiv · Sep 10, 2021Cancer Biology

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

S. A. Clark, L. E. Clark, J. Pan, A. Coscia, L. G. A. McKay, S. Shankar, R. I. Johnson, A. Griffiths, J. Abraham

The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.

bioRxiv · Nov 13, 2020Microbiology

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Z. A. Bittner, X. Liu, S. Shankar, A. Tapia Abellan, H. Kalbacher, L. Andreeva, M. Mangan, P. Duewell, M. Lovotti, K. Bosch, S. Dickhoefer, A. Marcu, S. Stevanovic, F. Herster, M. W. Loeffler, , A. N. Weber

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

bioRxiv · Jun 25, 2020Immunology

A low-cost and easy-to-use cell preservation reagent for 4{ring}C or room temperature sample storage

S. Shankar, S. Roy, A. Geary-Teeter, G. M. Martin, P. D. Ladd

This paper introduces a low-cost cell preservation reagent inspired by natural mechanisms, showing it preserves mammalian cells for at least one week at 4°C or as dried samples.

bioRxiv · Aug 23, 2019 · PreprintPathology

An Essential Role for Argonaute 2 in EGFR-KRAS Signaling in Pancreatic Cancer Development

S. Shankar, J. Tien, R. F. Siebenaler, S. Chugh, V. L. Dommeti, S. Zelenka-Wang, J. Waninger, K. M. Juckette, A. Xu, X.-M. Wang, M. Mody, S. Eyunni, A. Goodrum, G. Tsaloff, Y. Zhang, , A. M. Chinnaiyan

This study shows AGO2 is required for pancreatic cancer progression but not initiation, with its role dependent on mutant KRAS and EGFR signaling.

bioRxiv · Aug 1, 2019Cancer Biology