Author

Z. A. Bittner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:mouse· 1

Frequent Co-Authors

A. N. Weber· 2 shared B. Grimbacher· 2 shared A. Delor· 1 shared A. Marcu· 1 shared A. Pontillo· 1 shared A. Tapia Abellan· 1 shared B. Danker· 1 shared C. L. Greve· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. N. Weber

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2 papers

Recent·Most cited

BTK and MMP9 regulate NLRP3 inflammasome-dependent cytokine and NET responses in primary neutrophils.

V. N. C. Leal, F. Bork, J. C. von Guilleaume, C. L. Greve, S. Bugl, B. Danker, Z. A. Bittner, B. Grimbacher, A. Pontillo, A. N. Weber

This paper shows that BTK and MMP-9 negatively regulate NLRP3 inflammasome activity in neutrophils, affecting cytokine and NET release.

bioRxiv · Feb 23, 2024Immunology

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Z. A. Bittner, X. Liu, S. Shankar, A. Tapia Abellan, H. Kalbacher, L. Andreeva, M. Mangan, P. Duewell, M. Lovotti, K. Bosch, S. Dickhoefer, A. Marcu, S. Stevanovic, F. Herster, M. W. Loeffler, , A. N. Weber

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

bioRxiv · Jun 25, 2020Immunology