A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer
C. Jiang, N. P. Ward, N. Prieto-Farigua, Y. P. Kang, A. Thalakola, M. Teng, G. M. DeNicola
This study uses a CRISPR screen to identify redox vulnerabilities in KEAP1/NRF2 mutant NSCLC, finding that SOD2 loss enhances the efficacy of β-Lapachone by disrupting mitochondrial function.
bioRxiv · Mar 8, 2022Cancer Biology