Author

N. Prieto-Farigua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

G. M. DeNicola· 3 shared A. Falzone· 2 shared S. Caldwell· 2 shared A. Thalakola· 1 shared C. Jiang· 1 shared E. E. Schmidt· 1 shared E. R. Flores· 1 shared F. A. Karreth· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

G. M. DeNicola

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Author profile →

3 papers

Recent·Most cited

The Origin Of Cysteine and its Catabolism in Mammalian Tissues and Tumors

S. J. Yoon, J. A. Combs, A. Falzone, N. Prieto-Farigua, S. Caldwell, H. D. Ackerman, E. R. Flores, G. M. DeNicola

This study investigates cysteine metabolism in normal and tumor tissues using isotopic tracing, finding that cystine uptake is universal while de novo synthesis and catabolism vary across tissues and tumor types.

bioRxiv · Aug 26, 2022Cancer Biology

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

J. M. DeBlasi, A. Falzone, S. Caldwell, N. Prieto-Farigua, J. R. Prigge, E. E. Schmidt, I. I. C. Chio, F. A. Karreth, G. M. DeNicola

This study investigates the role of Nrf2 signaling thresholds in lung tumor initiation and progression using murine models with KEAP1 and NRF2 mutations.

bioRxiv · Aug 24, 2022Cancer Biology

A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer

C. Jiang, N. P. Ward, N. Prieto-Farigua, Y. P. Kang, A. Thalakola, M. Teng, G. M. DeNicola

This study uses a CRISPR screen to identify redox vulnerabilities in KEAP1/NRF2 mutant NSCLC, finding that SOD2 loss enhances the efficacy of β-Lapachone by disrupting mitochondrial function.

bioRxiv · Mar 8, 2022Cancer Biology