Author

M. Teng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. J. Groendyke· 2 shared B. L. Ebert· 2 shared B. Sandoval· 2 shared C. Jiang· 2 shared C. Y. Jin· 2 shared E. S. Fischer· 2 shared J. Qi· 2 shared K. Puvar· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

B. J. Groendyke

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program

L. Murray-Nerger, D. Maestri, X. Liu, Z. Li, I. Tempera, M. Teng, B. E. Gewurz

This study shows that WAPL suppresses LMP1 and LMP2A expression in EBV latency I by altering DNA looping and histone marks, preventing the transition to latency II.

bioRxiv · May 9, 2024Microbiology

Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

M. M. Hassan, Y.-D. Li, M. W. Ma, M. Teng, W. S. Byun, K. Puvar, R. Lumpkin, B. Sandoval, J. C. Rutter, C. Y. Jin, M. Y. Wang, S. Xu, A. M. Schmoker, H. Cheong, B. J. Groendyke, , N. Gray

This study evaluates how electrophilic modifications to JQ1 affect DCAF16 trans-labeling and BRD4 degradation, showing a correlation between warhead exposure and degradation efficiency.

bioRxiv · Oct 7, 2023 · PreprintPharmacology & Toxicology

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

Y.-D. Li, M. W. Ma, M. M. Hassan, M. Hunkeler, M. Teng, K. Puvar, R. Lumpkin, B. Sandoval, C. Y. Jin, S. B. Ficarro, M. Y. Wang, S. Xu, B. J. Groendyke, L. H. Sigua, I. Tavares, , B. L. Ebert

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

bioRxiv · Feb 14, 2023Biochemistry

A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer

C. Jiang, N. P. Ward, N. Prieto-Farigua, Y. P. Kang, A. Thalakola, M. Teng, G. M. DeNicola

This study uses a CRISPR screen to identify redox vulnerabilities in KEAP1/NRF2 mutant NSCLC, finding that SOD2 loss enhances the efficacy of β-Lapachone by disrupting mitochondrial function.

bioRxiv · Mar 8, 2022Cancer Biology

Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation

Y. Zhang, C. Jiang, S. J. Trudeau, Y. Narita, B. Zhao, M. Teng, R. Guo, B. Gewurz

This study identifies CAF1 and HIRA as host histone chaperones essential for maintaining Epstein-Barr virus latency by restricting lytic reactivation in Burkitt cells.

bioRxiv · Apr 28, 2020Microbiology