Author

N. P. Ward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. M. DeNicola· 5 shared Y. P. Kang· 3 shared A. Falzone· 2 shared A. F. Hazel· 1 shared A. Huebner· 1 shared A. R. Barber· 1 shared A. R. Huber· 1 shared A. Ruffini· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersCancer Biology

G. M. DeNicola

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Author profile →

5 papers

Recent·Most cited

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

H. E. Greenwood, R. S. Edwards, W. E. Tyrrell, A. R. Barber, F. Baark, M. Tanc, E. Khalil, A. Falzone, N. P. Ward, J. M. DeBlasi, L. Torrente, D. R. Pearce, G. Firth, L. M. Smith, O. Vilhelmsson Timmermand, , T. H. Witney

This study uses PET imaging to assess NRF2 activation in NSCLC, showing [18F]FSPG as a marker of therapeutic resistance and a potential target for treatment.

bioRxiv · Dec 16, 2023Cancer Biology

Glutathione supports lipid abundance in vivo

G. Asantewaa, E. T. Tuttle, N. P. Ward, Y. P. Kang, Y. Kim, M. E. Kavanagh, N. Girnius, Y. Chen, R. Duncan, K. Rodriguez, F. Hecht, M. Zocchi, L. Smorodintsev-Schiller, T. Q. Scales, K. Taylor, , I. S. Harris

This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.

bioRxiv · Feb 10, 2023 · PreprintBiochemistry

Mitochondrial Function is Preserved Under Cysteine Starvation via Glutathione Catabolism in NSCLC

N. P. Ward, S. J. Yoon, T. Flynn, A. Sherwood, J. Madej, G. M. DeNicola

The paper shows that mitochondrial function is preserved under cysteine starvation via glutathione catabolism in NSCLC cells, preventing ferroptosis.

bioRxiv · Oct 6, 2022Cancer Biology

A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer

C. Jiang, N. P. Ward, N. Prieto-Farigua, Y. P. Kang, A. Thalakola, M. Teng, G. M. DeNicola

This study uses a CRISPR screen to identify redox vulnerabilities in KEAP1/NRF2 mutant NSCLC, finding that SOD2 loss enhances the efficacy of β-Lapachone by disrupting mitochondrial function.

bioRxiv · Mar 8, 2022Cancer Biology

NNT Regulates Mitochondrial Metabolism in NSCLC Through Maintenance of Fe-S Protein Function

N. P. Ward, Y. P. Kang, A. Falzone, T. A. Boyle, G. M. DeNicola

This study shows NNT promotes NSCLC tumor growth by maintaining Fe-S protein function through NADPH production, preventing mitochondrial dysfunction and ROS accumulation.

bioRxiv · Sep 6, 2019Cancer Biology