Author

A. Tocheva

Brunel University of London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Kim-Schulze· 3 shared a. horowitz· 2 shared B. Lee· 2 shared C. Bieber· 2 shared E. Merritt· 2 shared K. G. Beaumont· 2 shared M. Garcia-Barros· 2 shared M. Tran· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

S. Kim-Schulze

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Author profile →

3 papers

Recent·Most cited

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

Bérengère Salomé, Haocheng Yu, Daniel L Ranti, Ying‐Chih Wang, C. Bieber, Pierre‐Etienne Gabriel, Igor Duquesne, Trine Strandgaard, B. Hug, Sean Houghton, Hiranmayi Ravichandran, Elliot Merritt, S. Bang, A. Demetriou, Z. Li, , Amir Horowitz

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

bioRxiv · Sep 2, 2024 · PreprintCancer Biology

Single cell view of tumor microenvironment gradients in pleural mesothelioma

B. Giotti, K. Dolasia, w. Zhao, P. Cai, R. Sweeney, E. Merritt, E. Kiner, G. Kim, A. Bhagwat, S. Hegde, B. Fitzgerald, S. Shroff, T. Dawson, M. Garcia-Barros, J. Abdul-Ghafar, , A. Tsankov

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

bioRxiv · Mar 14, 2024Cancer Biology

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

D. Ranti, Y.-S. Wang, J. Daza, C. Bieber, B. Salome, E. Merritt, J.-A. Cavallo, E. Hegewisch-Solloa, E. M. Mace, A. M. Farkas, S. Schroff, B. Lee, M. Tran, T. Strandgaard, S. V. Lindskrog, , A. Horowitz

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

bioRxiv · Mar 6, 2022 · PreprintImmunology