Organoid-T cell co-cultures functionally stratify tumor-reactive T cells and their responses to immune checkpoint inhibitors
Elliot Merritt, Julie-Ann Cavallo-Fleming, Genesis Lara Granados…·Anna S. Tocheva
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Icahn School of Medicine at Mount SinaiORCID 0000-0003-4091-8193Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Elliot Merritt, Julie-Ann Cavallo-Fleming, Genesis Lara Granados…·Anna S. Tocheva
Bérengère Salomé, Haocheng Yu, Daniel L Ranti…·Amir Horowitz
This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.
Bruno Giotti, Komal Dolasia, William Zhao…·Alexander M. Tsankov
This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.