Author

A. Bhagwat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Li· 2 shared V. Le Sage· 2 shared A. Alvarez Quilon· 1 shared A. Avery· 1 shared A. C. Hurt· 1 shared A. Cerutti· 1 shared A. Deshpande· 1 shared A. French· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersMicrobiology

C. Li

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single cell view of tumor microenvironment gradients in pleural mesothelioma

B. Giotti, K. Dolasia, w. Zhao, P. Cai, R. Sweeney, E. Merritt, E. Kiner, G. Kim, A. Bhagwat, S. Hegde, B. Fitzgerald, S. Shroff, T. Dawson, M. Garcia-Barros, J. Abdul-Ghafar, , A. Tsankov

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

bioRxiv · Mar 14, 2024Cancer Biology

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

J. Z. Zhou, B. Pei, G. Sun, M. Pawlitz, W. Zhang, x. Li, F. Yao, K. C. Hokynar, C.-X. Li, M. L. Perera, S. Wei, S. Zheng, L. A. Polin, J. M. Poulik, A. Ranki, , K. Chen

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

bioRxiv · Jan 10, 2024 · PreprintImmunology

Inoculum-dependent bactericidal activity of a Mycobacterium tuberculosis MmpL3 inhibitor

B. Berube, A. Deshpande, A. Bhagwat, T. Parish

The paper examines the bactericidal activity of NITD-349, an MmpL3 inhibitor, showing inoculum-dependent kill kinetics and enhanced efficacy when combined with isoniazid.

bioRxiv · Feb 22, 2023 · PreprintMicrobiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Pre-existing immunity provides a barrier to airborne transmission of influenza viruses

S. Lakdawala, V. Le Sage, J. Jones, K. Kormuth, W. Fitzsimmons, E. Nturibi, G. Padovani, C. Arevalo, A. French, A. Avery, R. Manivanh, E. E. McGrady, A. Bhagwat, A. S. Lauring, S. E. Hensley

The paper shows that pre-existing non-neutralizing immunity in ferrets blocks airborne transmission of seasonal influenza viruses.

PLOS Pathogens · Feb 18, 2021Peer-reviewedMicrobiology

FAM72A antagonizes UNG2 to promote mutagenic uracil repair during antibody maturation

Y. Feng, C. Li, J. Stewart, P. Barbulescu, N. Seija Desivo, A. Alvarez Quilon, R. Pezo, M. Perera, K. Chan, A. Tong, R. Mohamad-Ramshan, M. Berru, D. Nakib, G. Li, G. Kardar, , A. Martin

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

bioRxiv · Dec 23, 2020Immunology