T. Dawson

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Functional impairment of "helpless" CD8+ memory T cells is transient and driven by prolonged but finite cognate antigen presentation

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

Life stage impact on the human skin ecosystem: lipids and the microbial community

The paper investigates how life stages affect the human skin microbiome and lipid mediators, finding microbial correlations with lipid profiles and cytokine production.

Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos

This study identifies histone H1.2 as the carrier for PAR translocation from the nucleus to the cytosol, initiating parthanatos, and shows its role in neuronal injury models.

Flowers are leakier than leaves but cheaper to build

The paper compares the physiological costs of flowers and leaves across species, finding flowers have higher water loss but lower carbon investment.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

This study identifies shifts in lung macrophage composition linked to COVID-19 severity and recovery, suggesting therapeutic strategies targeting macrophage function.

Multimodal Single-Cell Characterization of the Human Granulocyte Lineage

This study uses multi-modal CITE-seq to accurately characterize human granulocytes, showing higher transcript detection with BD Rhapsody compared to 10X Genomics.

Using oxygen and hydrogen stable isotopes to track the migratory movement of Sharp-shinned Hawks (Accipiter striatus) along Western Flyways of North America

This study uses hydrogen and oxygen stable isotopes in feathers to track the natal origins of Sharp-shinned Hawks migrating along two flyways in North America, finding overlap in breeding origins but differing predictive power between isotope types.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

A novel virus alters gene expression and vacuolar morphology in Malassezia cells and induces a TLR3-mediated inflammatory immune response

The paper identifies a novel dsRNA virus in Malassezia restricta, shows it alters gene expression and cell morphology, and induces TLR3-mediated inflammation in dendritic cells.