Author

A. V. Signore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 6 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:multiple species· 3 Assay:proteomics· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. F. Storz· 4 shared A. Fago· 2 shared C. Natarajan· 2 shared F. G. Hoffmann· 2 shared K. L. Campbell· 2 shared A. Masse· 1 shared A. S. Lang· 1 shared A. Stoltzfus· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersEvolutionary Biology

J. F. Storz

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Avian influenza viruses in wild birds in Canada following incursion of the highly pathogenic H5N1 virus from Eurasia in 2021/2022

J. A. Giacinti, A. V. Signore, M. E. B. Jones, L. Bourque, S. Lair, C. Jardine, B. Stevens, T. Bollinger, D. Goldsmith, British Columbia Wildlife AIV Surveillance Program (BC WASP), M. Pybus, I. Stasiak, R. Davis, N. Pople, L. Nituch, , Thompson

This study tracks the spread of HPAIV H5N1 in Canadian wild birds after its 2021/2022 incursion, finding widespread infection across species and regions.

bioRxiv · Nov 23, 2023Zoology

Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller's sea cows

A. V. Signore, P. R. Morrison, C. J. Brauner, A. Fago, R. E. Weber, K. L. Campbell

This paper identifies an amino acid substitution in Steller's sea cow hemoglobin that altered oxygen affinity and solubility, contributing to their cold adaptation.

bioRxiv · Aug 29, 2022Evolutionary Biology

Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin

C. Natarajan, A. V. Signore, N. M. Bautista, F. G. Hoffmann, J. R. Tame, A. Fago, J. F. Storz

This study investigates the molecular basis of a novel allosteric property in crocodilian hemoglobin by resurrecting ancestral proteins and performing directed mutagenesis.

bioRxiv · Jul 18, 2022Evolutionary Biology

Evolved increases in hemoglobin-oxygen affinity and Bohr effect coincided with the aquatic specialization of penguins.

A. V. Signore, M. S. Tift, F. G. Hoffmann, T. L. Schmitt, H. Moriyama, J. F. Storz

This study investigates how penguins evolved increased hemoglobin-oxygen affinity and Bohr effect to enhance diving capabilities by optimizing oxygen extraction and release during breath-hold dives.

bioRxiv · Nov 17, 2020Evolutionary Biology

Biochemical paedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope

J. F. Storz, A. V. Signore

The paper identifies a developmental shift in gene expression in Tibetan antelopes that leads to increased blood-O2 affinity through juvenile hemoglobin isoform replacement, and reveals the genomic mechanism of this adaptation.

bioRxiv · Mar 20, 2020Evolutionary Biology

The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function

J. F. Storz, C. Natarajan, A. V. Signore, C. C. Witt, D. M. McCandlish, A. Stoltzfus

The paper examines how mutation bias at CpG dinucleotides influences adaptive molecular evolution by analyzing convergent changes in hemoglobin function across high-altitude birds.

bioRxiv · Mar 17, 2019Evolutionary Biology

Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

M. J. Gaudry, M. Jastroch, J. R. Treberg, M. Hofreiter, J. L. A. Paijmans, J. Starrett, N. Wales, A. V. Signore, M. S. Springer, K. L. Campbell

The paper shows that inactivation of UCP1 occurred in multiple placental mammal clades and is linked to reduced metabolic intensity and increased body mass during periods of global cooling.

Science Advances · Jul 7, 2017Peer-reviewedEvolutionary Biology