Author

A. Varrot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Organism:fungi (other)· 1 Organism:multiple species· 1

Frequent Co-Authors

A. Imberty· 2 shared A. Di Maio· 1 shared A. Titz· 1 shared D. Bojar· 1 shared D. Martinez-Alarcon· 1 shared E. Gillon· 1 shared E. Paci· 1 shared F. Bonnardel· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. Imberty

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Elucidating the Glycan-Binding Specificity and Structure of Cucumis melo Agglutinin, a New R-Type Lectin

J. Lundstrom, E. Gillon, V. Chazalet, N. Kerekes, A. Di Maio, Y. Liu, T. Feizi, A. Varrot, D. Bojar

This study characterizes Cucumis melo agglutinin (CMA1), revealing its glycan-binding specificity and 3D structure, and compares it to the R-type lectin RCA1.

bioRxiv · Nov 30, 2023 · PreprintBiochemistry

Bioinformatic, enzymatic and structural characterization of Trichuris suis hexosaminidase HEX-2

Z. Dutkiewicz, A. Varrot, K. J. Breese, K. A. Stubbs, L. Nuschy, I. Adduci, K. Paschinger, I. B. H. Wilson

This paper characterizes Trichuris suis HEX-2, a β-hexosaminidase, through bioinformatics, enzymatic assays, and structural analysis, revealing its substrate specificity and structural similarities to human enzymes.

bioRxiv · Nov 15, 2023 · PreprintBiochemistry

A pore-forming β-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3

S. Notova, F. Bonnardel, F. Rosato, L. Siukstaite, J. Schwaiger, N. Bovin, A. Varrot, W. Roemer, F. Lisacek, A. Imberty

The paper identifies a β-trefoil lectin from Salpingoeca rosetta that binds Gb3 and forms pores, leading to hemolysis and cancer cell toxicity.

bioRxiv · Feb 10, 2022 · PreprintBiochemistry

Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum

D. Martinez-Alarcon, V. Balloy, J.-P. Bouchara, R. J. Pieters, A. VARROT

This study identifies and characterizes SapL1, a lectin from Scedosporium apiospermum, showing its fucose-binding specificity and role in host cell adhesion.

bioRxiv · Nov 10, 2020 · PreprintBiochemistry

Induction of Rare Conformation of Oligosaccharide by Binding to Calcium-dependent Bacterial Lectin: X-ray Crystallography and Modelling Study

M. Lepsik, R. Sommer, S. Kuhaudomlarp, M. Lelimousin, E. Paci, A. Varrot, A. Titz, A. Imberty

The paper uses X-ray crystallography and theoretical chemistry to study how a bacterial lectin stabilizes an unusual oligosaccharide conformation, with implications for designing carbohydrate-based drugs.

bioRxiv · Apr 18, 2019Biophysics