Author

K. J. Breese

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Plant Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:Arabidopsis· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 1

Frequent Co-Authors

K. A. Stubbs· 4 shared J. S. Mylne· 3 shared C. S. Bond· 2 shared J. Haywood· 2 shared K. V. Sukhoverkov· 2 shared A. Varrot· 1 shared A. W. Debowski· 1 shared G. Vadlamani· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiochemistry

K. A. Stubbs

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4 papers

Recent·Most cited

Bioinformatic, enzymatic and structural characterization of Trichuris suis hexosaminidase HEX-2

Z. Dutkiewicz, A. Varrot, K. J. Breese, K. A. Stubbs, L. Nuschy, I. Adduci, K. Paschinger, I. B. H. Wilson

This paper characterizes Trichuris suis HEX-2, a β-hexosaminidase, through bioinformatics, enzymatic assays, and structural analysis, revealing its substrate specificity and structural similarities to human enzymes.

bioRxiv · Nov 15, 2023 · PreprintBiochemistry

A resistance-gene-directed tolerance trait and selective inhibitors proffer HMG-CoA reductase as a new herbicide mode of action

J. Haywood, K. J. Breese, J. Zhang, M. T. Waters, C. S. Bond, K. A. Stubbs, J. S. Mylne

The paper identifies HMGR as a potential herbicide target and demonstrates the design of specific inhibitors and a tolerance trait.

bioRxiv · Apr 18, 2022Plant Biology

Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam

G. Vadlamani, K. V. Sukhoverkov, J. Haywood, K. J. Breese, M. F. Fisher, K. A. Stubbs, C. S. Bond, J. S. Mylne

The paper solves the crystal structure of Arabidopsis thaliana HPPK/DHPS, revealing structural conservation with bacterial enzymes and exploring the herbicidal and antibacterial activity of asulam and related compounds.

bioRxiv · Nov 10, 2021Biochemistry

Inhibition of chloroplast translation as a new target for herbicides

K. V. Sukhoverkov, K. J. Breese, A. W. Debowski, M. W. Murcha, K. A. Stubbs, J. S. Mylne

This study identifies linezolid as a herbicide that inhibits chloroplast translation, showing it is effective against weeds and crops without directly affecting photosynthesis.

bioRxiv · Sep 28, 2021Plant Biology