W. Roemer

Real-time monitoring of cell surface protein arrival with split luciferases

This paper introduces a method using split luciferases to monitor real-time arrival of cell surface proteins in live cells with single-cell sensitivity.

The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains

This study investigates how the bacterial lectin LecA from P. aeruginosa alters membrane nanodomain organization by dispersing ordered domains using supported lipid bilayers.

A pore-forming β-trefoil lectin with specificity for the tumor-related glycosphingolipid Gb3

The paper identifies a β-trefoil lectin from Salpingoeca rosetta that binds Gb3 and forms pores, leading to hemolysis and cancer cell toxicity.

The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa

This study identifies CD59 and flotillins as key host proteins interacting with Pseudomonas aeruginosa's LecA, essential for bacterial invasion via a Gb3-enriched plasma membrane domain.

The Pseudomonas aeruginosa lectin LecB causes integrin internalization to facilitate crawling of bacteria underneath host cells

This paper shows that Pseudomonas aeruginosa's LecB lectin binds integrins and causes their internalization, enabling bacterial crawling under host cells.

Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

This study shows that Pseudomonas aeruginosa lectin LecB impairs keratinocyte proliferation and survival by disrupting growth factor signaling pathways.