Author

A. Vihervaara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

C. C. Friedel· 1 shared H. M. Haikala· 1 shared M. Barboric· 1 shared S. V. Himanen· 1 shared Z. Wang· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

C. C. Friedel

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1 paper

Recent·Most cited

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

Z. Wang, S. V. Himanen, H. M. Haikala, C. C. Friedel, A. Vihervaara, M. Barboric

This study shows that inhibiting CDK12 in cancer cells activates P-TEFb, leading to increased dependence on P-TEFb for transcriptional elongation and hypersensitivity to P-TEFb inhibitors.

bioRxiv · Mar 21, 2023Cancer Biology