Author

C. C. Friedel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:transcription & RNA processing· 2

Frequent Co-Authors

T. Hennig· 3 shared A. J. Rutkowski· 2 shared A. W. Whisnant· 2 shared B. Prusty· 2 shared F. Erhard· 2 shared L. Doelken· 2 shared M. Barboric· 2 shared N. J. Matheson· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

T. Hennig

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

Z. Wang, S. V. Himanen, H. M. Haikala, C. C. Friedel, A. Vihervaara, M. Barboric

This study shows that inhibiting CDK12 in cancer cells activates P-TEFb, leading to increased dependence on P-TEFb for transcriptional elongation and hypersensitivity to P-TEFb inhibitors.

bioRxiv · Mar 21, 2023Cancer Biology

Dissecting HSV-1-induced host shut-off at RNA level

C. C. Friedel, A. W. Whisnant, L. Djakovic, A. J. Rutkowski, M.-S. Friedl, M. Kluge, J. C. Williamson, S. Sai, R. O. Vidal, S. Sauer, T. Hennig, B. Prusty, P. J. Lehner, N. J. Matheson, F. Erhard, L. Dölken

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

bioRxiv · May 20, 2020 · PreprintMicrobiology

Integrative functional genomics decodes herpes simplex virus 1

A. W. Whisnant, C. S. Juerges, T. Hennig, E. Wyler, B. Prusty, A. J. Rutkowski, A. L'Hernault, M. Goebel, K. Doering, J. Menegatti, R. Antrobus, N. J. Matheson, F. W. Kuenzig, G. Mastrobuoni, C. Bielow, , L. Doelken

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

bioRxiv · Apr 9, 2019Microbiology

P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress

A. Bugai, A. J. Quaresma, C. C. Friedel, V. Lenasi, C. R. Sibley, P. Kukanja, K. Fujinaga, M. Blasius, T. Hennig, J. Ule, L. Doelken, M. Barboric

This study shows RBM7 activates P-TEFb to promote cell survival during genotoxic stress by enhancing Pol II elongation and transcription of DDR genes.

bioRxiv · Aug 17, 2018Biochemistry