Author

H. M. Haikala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Vihervaara· 1 shared C. C. Friedel· 1 shared E. Peuhu· 1 shared E.-M. Vesilahti· 1 shared H. Al-Akhrass· 1 shared J. Ivaska· 1 shared J. Klefström· 1 shared J. Lilja· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Vihervaara

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2 papers

Recent·Most cited

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

Z. Wang, S. V. Himanen, H. M. Haikala, C. C. Friedel, A. Vihervaara, M. Barboric

This study shows that inhibiting CDK12 in cancer cells activates P-TEFb, leading to increased dependence on P-TEFb for transcriptional elongation and hypersensitivity to P-TEFb inhibitors.

bioRxiv · Mar 21, 2023Cancer Biology

Sortilin-related receptor is a druggable therapeutic target in breast cancer

H. Al-Akhrass, M. Pietilä, J. Lilja, E.-M. Vesilahti, J. M. Anttila, H. M. Haikala, P. M. Munne, J. Klefström, E. Peuhu, J. Ivaska

This study shows that targeting SorLA with a monoclonal antibody can overcome HER2 resistance in breast cancer, both in vitro and in vivo.

bioRxiv · Mar 9, 2021Cancer Biology