A. W. Murray

Modeling the impact of single-cell stochasticity and size control on the population growth rate in asymmetrically dividing cells

The paper models how single-cell stochasticity and size control affect population growth rates in asymmetrically dividing cells, finding that asymmetric division can enhance growth rates under strong size control.

Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics

The paper models and experiments with yeast toxin release to study microbial antagonism dynamics in spatial and well-mixed populations.

Rapid toxin sequestration modifies poison frog physiology

This study shows poison frogs rapidly accumulate toxins, altering protein abundance in immune response and small molecule transport across tissues.

Bet hedging buffers budding yeast against environmental instability

The paper shows that budding yeast use bet hedging to adapt to environmental changes by maintaining subpopulations with different metabolic strategies.

Many but not all lineage-specific genes can be explained by homology detection failure

The paper tests whether lineage-specific genes can be explained by homology detection failure in fungi and insects, finding most are explained but some require further study.

Cell size regulation in budding yeast does not depend on linear accumulation of Whi5

This study challenges a model of cell size control in budding yeast by showing that altering Whi5 concentration via inducible promoter does not disrupt size regulation.

Evolutionary repair: changes in multiple functional modules allow meiotic cohesin to support mitosis

This study shows that evolving yeast to use meiosis-specific Rec8 in mitosis requires changes in transcriptional mediators and cell cycle regulators, not Rec8 itself, to improve sister chromosome cohesion.

Selecting for altered substrate specificity reveals the evolutionary flexibility of ATP-binding cassette transporters

This study mutagenizes and selects for altered substrate specificity in an ABC transporter to explore evolutionary flexibility in substrate selectivity.

The evolutionary plasticity of chromosome metabolism allows adaptation to DNA replication stress

This study shows that chromosome metabolism can evolve under DNA replication stress in yeast, with consistent pathway changes across populations.

Independent evolution of polymerization in the Actin ATPase clan regulates hexokinase activity

Yeast glucokinase activity is limited by its polymerization, which is critical for cell viability during glucose refeeding.

Seasonal changes in diet and toxicity in the Climbing Mantella frog (Mantella laevigata)

This study examines how seasonal environmental changes affect the diet and toxin profiles of Climbing Mantella frogs, finding seasonal differences in diet composition and toxin abundance.

Physical interactions reduce the power of natural selection in growing yeast colonies

The paper shows physical interactions in yeast colonies reduce natural selection's power, maintaining genetic diversity and slowing takeover by faster-growing strains.

Genetic Drift and Selection in Many-Allele Range Expansions

The paper investigates evolutionary dynamics in expanding E. coli colonies using experiments and simulations, showing that a random-walk model accurately predicts genetic domain behavior with three key parameters.