Author

S. Srikant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:E. coli· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1

Frequent Co-Authors

M. T. Laub· 3 shared M. LeRoux· 2 shared R. Gaudet· 2 shared A. Cepauskas· 1 shared A. Garcia-Pino· 1 shared A. Leung· 1 shared A. Talavera· 1 shared A. W. Murray· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersMicrobiology

M. T. Laub

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Direct activation of an innate immune system in bacteria by a viral capsid protein

T. Zhang, H. Tamman, K. Coppieters't Wallant, T. Kurata, M. LeRoux, S. Srikant, T. Brodiazhenko, A. Cepauskas, A. Talavera, C. Martens, G. C. Atkinson, V. Hauryliuk, A. Garcia-Pino, M. T. Laub

This study identifies a bacterial immune system that directly senses a viral capsid protein through a toxin-antitoxin system, revealing a PAMP-like mechanism for innate immunity in bacteria.

bioRxiv · May 30, 2022 · PreprintMicrobiology

The evolution of a counter-defense mechanism in a virus constrains its host range

S. Srikant, C. K. Guegler, M. T. Laub

This study experimentally evolves T4 phage to overcome E. coli's toxin-antitoxin system, revealing a trade-off where counter-defense mechanisms constrain host range.

bioRxiv · Apr 14, 2022Microbiology

Natural transformation protein ComFA exhibits single-stranded DNA translocase activity

H. R. Foster, X. Lin, S. Srikant, R. R. Cueny, T. G. Falbel, J. L. Keck, R. Gaudet, B. M. Burton

This study investigates ComFA's role in natural transformation by demonstrating its single-stranded DNA translocase activity and ATP-dependent DNA release mechanism.

bioRxiv · Oct 29, 2021Microbiology

The DarTG toxin-antitoxin system provides phage defense by ADP-ribosylating viral DNA

M. LeRoux, S. Srikant, M. L. Littlehale, G. Teodoro, S. Doron, M. Badiee, A. Leung, R. Sorek, M. T. Laub

This study identifies DarTG toxin-antitoxin systems in E. coli that defend against phage by ADP-ribosylating viral DNA, with phages evolving resistance through DNA polymerase or anti-DarT factors.

bioRxiv · Sep 27, 2021 · PreprintMicrobiology

Selecting for altered substrate specificity reveals the evolutionary flexibility of ATP-binding cassette transporters

S. Srikant, R. Gaudet, A. W. Murray

This study mutagenizes and selects for altered substrate specificity in an ABC transporter to explore evolutionary flexibility in substrate selectivity.

bioRxiv · Oct 8, 2019Evolutionary Biology