A. W. Reinke

This study examines how protein reduction in microsporidia affects function, showing that most proteins cannot complement yeast orthologs and are more reduced in length.

The paper screens the Pandemic Response Box to identify anti-microsporidia compounds using C. elegans infected with Nematocida parisii, finding four effective inhibitors.

This study sequenced nine nematode-infecting microsporidia genomes, revealing conserved metabolic pathways, horizontally transferred genes, and variable phenotypic traits across species.

This study screens FDA-approved compounds and natural products to identify inhibitors of microsporidia infection in C. elegans, finding five compounds that block spore firing and one that slows infection progression.

This study identifies a secreted host protein, AAIM-1, that promotes microsporidia invasion of C. elegans and reveals trade-offs in host defense against different pathogens.

The paper creates a database of 1,440 microsporidia species and analyzes their ecological and phenotypic diversity, finding broad host ranges and polar tube length as a determinant of tissue specificity.

The paper shows that parental transcriptional responses to microsporidia infection induce inherited immunity in offspring, protecting them against both microsporidia and bacterial pathogens.