A. W. Segal

Ulcerative colitis is characterized by amplified acute inflammation with delayed resolution

This study shows that ulcerative colitis patients have exaggerated and prolonged inflammatory responses to bacterial injection, which are mitigated by 5-aminosalicylates through pro-resolution lipid pathways.

Similar distribution of T-cell subsets in Crohn's disease and in diverticulitis provide evidence against a primary causal role for these cells in Crohn's

The study compares T-cell subset distribution in Crohn's disease and diverticulitis, finding no differences, suggesting T-cell accumulation is a secondary immune response rather than a primary cause of Crohn's.

Variations in the phagosomal environment of human neutrophils and mononuclear phagocyte subsets.

This study compares phagosomal pH across human neutrophils and mononuclear phagocyte subsets, revealing significant differences that affect enzyme activity and function.

Evidence against the microbicidal action of neutrophil extracellular traps (NETs)

The paper challenges the claim that neutrophil extracellular traps (NETs) kill microbes by showing that DNA digestion after incubation restores microbial numbers, suggesting the observed effect is an assay artifact.

The human oral microbiome is shaped by shared environment rather than genetics: evidence from a large family of closely-related individuals

This study shows that shared environment, not genetics, shapes the oral microbiome in a large family, with household effects persisting even after individuals move out.