A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models
A. Wolter, C. H. Bucher, S. Kurmies, V. Schreiner, F. Konietschke, K. Hohlbaum, R. Klopfleisch, M. Loehning, C. Thoene-Reineke, F. Buttgereit, J. Huwyler, P. Jirkof, A. E. Rapp, A. Lang
This study evaluates a new Buprenorphine depot formulation (BUP-Depot) for sustained post-surgical analgesia in mouse femoral fracture models, finding it effective for 72h and comparable to Tramadol in drinking water.
bioRxiv · Jul 5, 2022 · PreprintAnimal Behavior & Cognition