Author

M. Loehning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Animal Behavior & Cognition· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Lang· 2 shared A. N. Hegazy· 2 shared A. Wolter· 2 shared C. Peine· 2 shared F. Buttgereit· 2 shared M. Peine· 2 shared T. Hoefer· 2 shared A. Damerau· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersAnimal Behavior & Cognition

A. Lang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

I. Roewekamp, L. Maschirow, A. Rabes, F. Fiocca Vernengo, G. A. Heinz, M.-F. Mashreghi, S. Caesar, M. Milek, A. Fagundes, S.-M. Wienhold, G. Nouailles, L. Yao, D. Bruder, J. Boehme, M. Puzianowska-Kuznicka, , B. Opitz

This study shows IL-33 reduces IL-22 production in innate lymphoid cells, increasing resistance to Streptococcus pneumoniae infection, and links genetic variation in IL-33 signaling to human pneumonia.

bioRxiv · Jul 19, 2023Immunology

Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities

A. N. Hegazy, C. Peine, D. Niesen, I. Panse, Y. Vainshtein, C. Kommer, Q. Zhang, T. M. Brunner, M. Peine, A. Froehlich, N. Ishaque, R. M. Marek, J. J. Zhu, T. Hoefer, M. Loehning

This study shows that T-bet expression levels in Th1 cells determine their plasticity and lineage stability, with virus-induced interferons regulating these states.

bioRxiv · Aug 14, 2022 · PreprintImmunology

A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models

A. Wolter, C. H. Bucher, S. Kurmies, V. Schreiner, F. Konietschke, K. Hohlbaum, R. Klopfleisch, M. Loehning, C. Thoene-Reineke, F. Buttgereit, J. Huwyler, P. Jirkof, A. E. Rapp, A. Lang

This study evaluates a new Buprenorphine depot formulation (BUP-Depot) for sustained post-surgical analgesia in mouse femoral fracture models, finding it effective for 72h and comparable to Tramadol in drinking water.

bioRxiv · Jul 5, 2022 · PreprintAnimal Behavior & Cognition

High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells

P. Burt, M. Peine, C. Peine, Z. Borek, S. Serve, M. Flossdorf, A. N. Hegazy, T. Hoefer, M. Loehning, K. Thurley

This study analyzes the dynamic transcriptome of Th cell differentiation, revealing a unique STAT-dependent transcriptional program in Th1/2 hybrid cells.

bioRxiv · May 13, 2022Immunology

HIF-stabilization prevents delayed fracture healing

A. Lang, S. Helfmeier, J. Stefanowski, A. Kuppe, V. Sunkara, M. Pfeiffenberger, A. Wolter, A. Damerau, S. Hemmati-Sadeghi, J. Ringe, R. Haag, A. E. Hauser, M. Loehning, C. Perka, G. N. Duda, , F. Buttgereit

This study shows that stabilizing HIF-1α with deferoxamine and macrophage migration inhibitory factor improves fracture healing in a mouse model by enhancing calcification, osteogenic differentiation, and vascularization.

bioRxiv · Jul 2, 2020Bioengineering