G. N. Duda

Anisotropic Hydrogel Degradation Enhances 3D Collective Mesenchymal Stromal Cell Alignment, Mechanotransduction and Osteogenic Differentiation

This paper shows that anisotropic hydrogel degradation patterns enhance hMSC alignment, mechanotransduction, and osteogenic differentiation compared to uniform materials.

Aging impairs skeletal muscle regeneration by promoting fibro/fatty degeneration and inhibiting inflammation resolution via fibro-adipogenic progenitors

This study shows aging impairs muscle regeneration by promoting fibro/fatty degeneration and inhibiting inflammation resolution through reduced Periostin in fibro/adipogenic progenitors.

Hydrogels with stiffness-degradation spatial patterns control anisotropic 3D cell response

This study develops hydrogels with spatial stiffness-degradation patterns to control anisotropic 3D cell response, showing changes in cell morphology and proliferation over time.

From breast cancer cell homing to the onset of early bone metastasis: dynamic bone (re)modeling as a driver of metastasis

This study develops a mouse model and multimodal 3D imaging to analyze cancer cell homing and dynamic bone remodeling during early bone metastasis, revealing osteolytic lesions in specific bone regions.

In vivo validation of spray-dried mesoporous bioactive glass microspheres acting as prolonged local release systems for BMP-2 to induce bone regeneration

This study validates spray-dried mesoporous bioactive glass microspheres as a prolonged BMP-2 release system to enhance bone regeneration with reduced side effects.

HIF-stabilization prevents delayed fracture healing

This study shows that stabilizing HIF-1α with deferoxamine and macrophage migration inhibitory factor improves fracture healing in a mouse model by enhancing calcification, osteogenic differentiation, and vascularization.