Commensal-specific CD4 T cells promote inflammation in the central nervous system via molecular mimicry
Z. White, I. Cabrera, A. Ochoa-Raya, I. Kapustka, K. P. Koster, T. Matsuo, D. Jayawardena, T. Kageyama, P. K. Dudeja, S. E. Lutz, A. Yoshii, T. Sano
This study shows that specific T cells recognizing commensal bacteria can cause CNS inflammation through molecular mimicry of host proteins.
bioRxiv · Sep 27, 2022 · PreprintImmunology