Toxin-mediated downregulation of absorptive ion transporters NHE3, DRA, and SGLT1 in the colon contributes to diarrhea associated with Clostridioides difficile infection.
F. C. Peritore-Galve, I. Kaji, A. Smith, L. M. Walker, J. A. Shupe, P. K. Dudeja, J. R. Goldenring, D. B. Lacy
This study shows CDI reduces NHE3, DRA, and SGLT1 in the colon, impairing ion transport and causing osmotic diarrhea.
bioRxiv · Nov 12, 2022 · PreprintPhysiology