Endothelial Caveolin-1 and CXCL10 promote transcellular migration of autoreactive T cells across the blood-brain barrier
T. N. Trevino, A. A. Almousawi, A. Ochoa-Raya, K. Zemanski, S. D. Oliveira, F. M. Marottoli, L. M. Tai, R. D. Minshall, S. E. Lutz
This study shows that Caveolin-1 in brain endothelial cells stores CXCL10 to facilitate transcellular migration of autoreactive T cells across the blood-brain barrier, reducing neuroinflammation in EAE.
bioRxiv · Nov 15, 2022 · PreprintImmunology