ImmunologybioRxiv
A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes
C. Wilder, D. Lefaudeux, R. Mathenge…·A. Hoffmann
The paper shows high-dose IFN-β activates a pro-inflammatory gene program through a stimulus-contingent positive feedback loop in ISGF3, unlike IFN-λ3.
DOI 10.15252/msb.202211294