R. Mathenge

An integrated signaling threshold initiates IgG response towards virus-like immunogens

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.

A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes

The paper shows high-dose IFN-β activates a pro-inflammatory gene program through a stimulus-contingent positive feedback loop in ISGF3, unlike IFN-λ3.