Q. J. Cheng

Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks

This study compares the training effects of different Dectin-1 ligands on human monocytes and finds that zymosan induces a distinct phenotype compared to β-glucan through differential activation of signaling pathways.

A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes

The paper shows high-dose IFN-β activates a pro-inflammatory gene program through a stimulus-contingent positive feedback loop in ISGF3, unlike IFN-λ3.