Author

D. Howie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:flow cytometry· 1

Frequent Co-Authors

S. P. Cobbold· 2 shared A. Cooke· 1 shared A. Grottesi· 1 shared A. Handel· 1 shared A. Lloyd· 1 shared A. Recino· 1 shared A. Schmidt-Christensen· 1 shared A. W. Purcell· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

S. P. Cobbold

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Author profile →

5 papers

Recent·Most cited

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

T. V. Cornforth, N. A. Moyo, S. Cole, E. Lam, T. Lobry, R. Wolchinsky, A. Lloyd, K. Ward, E. M. Denham, G. S. Besra, N. Veerapen, P. T. Illing, J. P. Vivian, J. M. Raynes, J. Le Nours, , J. Dukes

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

bioRxiv · Jul 17, 2023Cancer Biology

A role of Lck annular lipids in the steady upkeep of active Lck in T cells

N. Porciello, D. Cipria, G. Masi, A.-L. Lanz, E. Milanetti, A. Grottesi, D. Howie, S. P. Cobbold, L. Schermelleh, M. D'Abramo, H.-T. He, N. Destainville, O. Acuto, K. Nika

The paper investigates how annular lipids affect Lck kinase activity in T cells by examining the balance between autophosphorylation and dephosphorylation by CD45.

bioRxiv · Mar 18, 2022 · PreprintCell Biology

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

B. E. Oftedal, S. Maio, A. Handel, M. P. White, D. Howie, S. Davis, N. Prevot, I. A. Rota, M. E. Deadman, B. M. Kessler, R. Fisher, N. S. Trede, E. Sezgin, R. M. Maizels, G. A. Hollander

This study shows that the chaperonin CCT8 is essential for T cell maturation, selection, and function by maintaining proteostasis, and its absence impairs immune protection against helminths.

bioRxiv · Aug 11, 2020Immunology

GLP-1R is downregulated in beta cells of NOD mice and T1D patients

A. Recino, K. Barkan, A. Schmidt-Christensen, J. Nilsson, N. Holmes, D. Howie, D. Holmberg, P. Larsson, M. Flodstrom-Tullberg, L. Laraia, D. R. Spring, J. Hecksher-Sorensen, A. Cooke, G. Ladds, M. Wallberg

This study shows that GLP-1R is downregulated in beta cells of NOD mice and T1D patients, likely due to accelerated degradation, and suggests a role in autoimmune inflammation.

bioRxiv · Nov 17, 2019 · PreprintPhysiology

CD4+ T cell fate decisions are stochastic, precede cell division, depend on GITR co-stimulation, and are associated with uropodium development

S. P. Cobbold, E. Adams, D. Howie, H. Waldmann

The paper shows CD4+ T cell fate decisions are stochastic, occur before division, depend on GITR co-stimulation, and link to uropodium development and lineage-specific signaling.

bioRxiv · Apr 9, 2018Immunology