Author

L. Schermelleh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:imputation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Organism:Drosophila· 1

Frequent Co-Authors

J. Godwin· 2 shared K. Nasmyth· 2 shared A. Gerondopoulos· 1 shared A. Grottesi· 1 shared A. Houtsmuller· 1 shared A. Presser Aiden· 1 shared A. R. Faria· 1 shared A. Rattani· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

J. Godwin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics

J. Wang, D. Stoychev, M. Phillips, D. M. S. Pinto, R. M. Parton, N. Hall, J. Titlow, A. R. Faria, M. Wincott, D. Gala, A. Gerondopoulos, N. Irani, I. Dobbie, L. Schermelleh, M. Booth, I. Davis

This paper introduces Deep3DSIM, an upright 3D-SIM system with adaptive optics for deep tissue imaging, achieving high-quality imaging up to 130 micrometers in Drosophila brain.

bioRxiv · Dec 21, 2023Cell Biology

A role of Lck annular lipids in the steady upkeep of active Lck in T cells

N. Porciello, D. Cipria, G. Masi, A.-L. Lanz, E. Milanetti, A. Grottesi, D. Howie, S. P. Cobbold, L. Schermelleh, M. D'Abramo, H.-T. He, N. Destainville, O. Acuto, K. Nika

The paper investigates how annular lipids affect Lck kinase activity in T cells by examining the balance between autophosphorylation and dephosphorylation by CD45.

bioRxiv · Mar 18, 2022 · PreprintCell Biology

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.

M. Houlard, E. Cutts, M. S. Shamim, J. Godwin, D. Weisz, A. Presser Aiden, E. Lieberman Aiden, L. Schermelleh, A. Vannini, K. Nasmyth

This paper shows MCPH1 inhibits condensin II during interphase by binding to NCAPG2, preventing chromosome condensation, and demonstrates that this regulation is essential for maintaining chromatin structure.

bioRxiv · Jul 20, 2021Cell Biology

Structured illumination microscopy with noise-controlled image reconstructions

C. S. Smith, J. Slotman, L. Schermelleh, N. Chakrova, S. Hari, Y. Vos, C. W. Hagen, M. Mueller, W. van Cappellen, A. Houtsmuller, J. P. Hoogenboom, S. Stallinga

This paper introduces noise-controlled reconstruction methods for structured illumination microscopy to reduce artefacts and improve image quality.

bioRxiv · Mar 11, 2021Biophysics

Loss of Sister Kinetochore Co-orientation and Peri-centromeric Cohesin Protection after Meiosis I Depends on Cleavage of Centromeric REC8

S. Ogushi, A. Rattani, J. Godwin, J. Metson, L. Schermelleh, K. Nasmyth

The paper shows that cleavage of REC8 in meiosis I is essential for sister kinetochore co-orientation loss and peri-centromeric cohesin deprotection, which are necessary for sister chromatid disjunction.

bioRxiv · Feb 6, 2020Cell Biology